phenobarbital raises toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers may increase the metabolism of ifosfamide to its Energetic alkylating metabolites.Stay clear of; coadministration with CYP3A inducers could lead to diminished plasma concentrations of elvitegravir and/or maybe a c… Read More